Date Last
Modified: 09/29/2003
Table of Contents
Note: Separate PDQ summaries on Prevention of Lung Cancer and Screening for Lung Cancer are also available.
Non-small cell lung cancer (NSCLC) is a heterogeneous aggregate of at least 3 distinct histologies of lung cancer including epidermoid or squamous carcinoma, adenocarcinoma, and large cell carcinoma. These histologies are often classified together because, when localized, all have the potential for cure with surgical resection. Systemic chemotherapy can produce objective partial responses and palliation of symptoms for short durations in patients with advanced disease. Local control can be achieved with radiation in a large number of patients with unresectable disease, but cure is seen only in a small minority of patients.
At diagnosis, patients with NSCLC can be divided into 3 groups that reflect the extent of disease and treatment approach:
The first group of patients has tumors that are surgically resectable (generally stages I and II). This is the group with the best prognosis, depending on a variety of tumor and host factors. Patients with resectable disease who have medical contraindications to surgery can be considered for curative radiation therapy.
The second group includes patients with either locally (T3-T4) or regionally (N2-N3) advanced lung cancer who have a diverse natural history. This group is treated with radiation therapy or, more commonly, with radiation therapy in combination with chemotherapy or other therapy modalities. Selected patients with T3 or N2 disease can be treated effectively with surgical resection alone.
The final group of patients have distant metastases (M1) found at the time of diagnosis. This group can be treated with radiation therapy or chemotherapy for palliation of symptoms from the primary tumor. Patients with good performance status, women, and patients with distant metastases confined to a single site appear to live longer than others.[1] Cisplatin-based chemotherapy has been associated with short-term palliation of symptoms and a small survival advantage. Currently no single chemotherapy regimen can be recommended for routine use.
For patients with operable disease, prognosis is adversely influenced by the presence of pulmonary symptoms, large tumor size (>3 centimeters), and presence of the erbB-2 oncoprotein.[1-6] Other factors that have been identified as adverse prognostic factors in some series of patients with resectable non-small cell lung cancer include mutation of the K-ras gene, vascular invasion, and increased numbers of blood vessels in the tumor specimen.[3,7,8]
For patients with inoperable disease, prognosis is adversely affected by poor performance status and weight loss of greater than 10%. In multiple retrospective analyses of clinical trial data, advanced age alone has not been shown to influence response or survival with therapy.[9]
Since treatment is not satisfactory for almost all patients with NSCLC, with the possible exception of a subset of patients with pathologic stage I (T1, N0, M0) disease treated surgically, eligible patients should be considered for clinical trials.
References
Albain KS, Crowley JJ, LeBlanc M, et al.: Survival determinants in extensive-stage non-small-cell lung cancer: the Southwest Oncology Group experience. J Clin Oncol 9 (9): 1618-26, 1991. [PUBMED Abstract]
Macchiarini P, Fontanini G, Hardin MJ, et al.: Blood vessel invasion by tumor cells predicts recurrence in completely resected T1 N0 M0 non-small-cell lung cancer. J Thorac Cardiovasc Surg 106 (1): 80-9, 1993. [PUBMED Abstract]
Harpole DH Jr, Herndon JE 2nd, Wolfe WG, et al.: A prognostic model of recurrence and death in stage I non-small cell lung cancer utilizing presentation, histopathology, and oncoprotein expression. Cancer Res 55 (1): 51-6, 1995. [PUBMED Abstract]
Ichinose Y, Yano T, Asoh H, et al.: Prognostic factors obtained by a pathologic examination in completely resected non-small-cell lung cancer. An analysis in each pathologic stage. J Thorac Cardiovasc Surg 110 (3): 601-5, 1995. [PUBMED Abstract]
Martini N, Bains MS, Burt ME, et al.: Incidence of local recurrence and second primary tumors in resected stage I lung cancer. J Thorac Cardiovasc Surg 109 (1): 120-9, 1995. [PUBMED Abstract]
Strauss GM, Kwiatkowski DJ, Harpole DH, et al.: Molecular and pathologic markers in stage I non-small-cell carcinoma of the lung. J Clin Oncol 13 (5): 1265-79, 1995. [PUBMED Abstract]
Slebos RJ, Kibbelaar RE, Dalesio O, et al.: K-ras oncogene activation as a prognostic marker in adenocarcinoma of the lung. N Engl J Med 323 (9): 561-5, 1990. [PUBMED Abstract]
Fontanini G, Bigini D, Vignati S, et al.: Microvessel count predicts metastatic disease and survival in non-small cell lung cancer. J Pathol 177 (1): 57-63, 1995. [PUBMED Abstract]
Earle CC, Tsai JS, Gelber
RD, et al.: Effectiveness of chemotherapy for advanced lung cancer in the elderly:
instrumental variable and propensity analysis. J Clin Oncol 19 (4): 1064-70,
2001. [PUBMED Abstract]
Prior to initiating treatment of any patient with lung cancer, a review of pathologic material by an experienced lung cancer pathologist is critical since some cases of small cell lung cancer (which responds well to chemotherapy) can be confused on microscopic examination with non-small cell carcinoma.[1] Nonsquamous cell cancers may be more likely to recur after surgical resection of early stage I tumors than other types of non-small cell lung cancers.[2]
Bronchoalveolar carcinoma represents 10% to 25% of adenocarcinomas and sometimes has a distinct presentation and biologic behavior.[3-5] Bronchoalveolar cancer may present as a more diffuse lesion than other types of cancer; 30% to 40% of patients undergoing an attempt at surgical resection present with an infiltrate on their chest radiograph. Bronchoalveolar cancer is more common in women and in patients who do not smoke cigarettes than other histologic types of lung cancer.
Histologic classification
of non-small cell lung cancer:
Squamous cell (epidermoid) carcinoma.
Spindle cell variant.
Adenocarcinoma.
Acinar.
Papillary.
Bronchoalveolar.[4,5]
Solid tumor with mucin.
Large cell carcinoma.
Giant cell.
Clear cell.
Adenosquamous carcinoma.
Undifferentiated carcinoma.
References
Kreyberg L, Liebow AA, Uehlinger EA: International Histologic Classification of Tumours: No. 1. Histological Typing of Lung Tumours. 2nd ed. Geneva: World Health Organization, 1981.
Thomas P, Rubinstein L: Cancer recurrence after resection: T1 N0 non-small cell lung cancer. Lung Cancer Study Group. Ann Thorac Surg 49 (2): 242-6; discussion 246-7, 1990. [PUBMED Abstract]
Harpole DH, Bigelow C, Young WG Jr, et al.: Alveolar cell carcinoma of the lung: a retrospective analysis of 205 patients. Ann Thorac Surg 46 (5): 502-7, 1988. [PUBMED Abstract]
Grover FL, Piantadosi S: Recurrence and survival following resection of bronchioloalveolar carcinoma of the lung--The Lung Cancer Study Group experience. Ann Surg 209 (6): 779-90, 1989. [PUBMED Abstract]
Daly RC, Trastek VF, Pairolero PC, et al.: Bronchoalveolar carcinoma: factors affecting survival. Ann Thorac Surg 51 (3): 368-76; discussion 376-7, 1991. [PUBMED Abstract]
Since determination of stage has important therapeutic and prognostic implications, careful initial diagnostic evaluation to define location and extent of primary and metastatic tumor involvement is critical for the appropriate care of patients.
Stage has a critical role in the selection of therapy. The stage of disease is based on a combination of clinical (physical examination, radiologic, and laboratory studies) and pathologic (biopsy of lymph nodes, bronchoscopy, mediastinoscopy, or anterior mediastinotomy) factors.[1] The distinction between clinical stage and pathologic stage should be considered when evaluating reports of survival outcome. Surgical staging of the mediastinum is considered standard if accurate evaluation of the nodal status is needed to determine therapy. The Radiology Diagnostic Oncology Group reported that the sensitivity and specificity of computed tomographic (CT) scanning is only 52% and 69%, respectively.[2] Magnetic resonance imaging does not appear to improve the accuracy of staging.[2] Early evaluation of the role of positron emission tomography (PET) suggests that the combination of CT and PET may have greater sensitivity and specificity than CT alone.[3] A report evaluating the staging of 1,400 patients undergoing tumor resection found that clinical staging by radiologic studies accurately assessed the T stage in 78% of patients and the N stage in only 47% of patients. Errors in clinical staging were equally divided between overstaging and understaging.[4]
The Revised International Staging System for Lung Cancer
The Revised International System for Staging Lung Cancer was adopted in 1997 by the American Joint Committee on Cancer and the Union Internationale Contre le Cancer.[5] These revisions were made to provide greater specificity for patient groups. Stage I is divided into 2 categories by the size of the tumor; IA, T1N0M0 and IB, T2N0M0. Stage II is divided into 2 categories by the size of the tumor and by the nodal status; IIA, T1N1M0 and IIB, T2N1M0. T3N0 has been moved from stage IIIA in the 1986 version of the staging system to stage IIB. The other change has been to clarify the classification of multiple tumor nodules. Satellite tumor nodules in the same lobe as the primary lesion that are not lymph nodes should be classified as T4 lesions. Intrapulmonary ipsilateral metastasis in a lobe other than the lobe containing the primary lesions should be classified as an M1 lesion (stage IV).
The American Joint Committee on Cancer (AJCC) has designated staging by TNM classification.[6]
Primary tumor (T)
TX: Primary tumor cannot be assessed, or tumor proven by the presence of malignant cells in sputum or bronchial washings but not visualized by imaging or bronchoscopy
T0: No evidence of primary tumor
Tis: Carcinoma in situT1: A tumor that is 3 cm or less in greatest dimension, surrounded by lung or visceral pleura, and without bronchoscopic evidence of invasion more proximal than the lobar bronchus (i.e., not in the main bronchus). [Note: The uncommon superficial tumor of any size with its invasive component limited to the bronchial wall, which may extend proximal to the main bronchus, is also classified as T1.]
T2: A tumor with any of the following features of size or extent:More than 3 cm in greatest dimension
Involves the main bronchus, 2 cm or more distal to the carina
Invades the visceral pleura
Associated with atelectasis or obstructive pneumonitis that extends to the hilar region but does not involve the entire lungT3: A tumor of any size that directly invades any of the following: chestwall (including superior sulcus tumors), diaphragm, mediastinal pleura, parietal pericardium; or tumor in the main bronchus less than 2 cm distal to the carina but without involvement of the carina; or associated atelectasis or obstructive pneumonitis of the entire lung
T4: A tumor of any size that invades any of the following: mediastinum, heart, great vessels, trachea, esophagus, vertebral body, carina; or separate tumor nodules in the same lobe; or tumor with a malignant pleural effusion. [Note: Most pleural effusions associated with lung cancer are due to tumor. However, there are a few patients in whom multiple cytopathologic examinations of pleural fluid are negative for tumor. In these cases, fluid is nonbloody and is not an exudate. Such patients may be further evaluated by videothoracoscopy (VATS) and direct pleural biopsies. When these elements and clinical judgement dictate that the effusion is not related to the tumor, the effusion should be excluded as a staging element and the patient should be staged as T1, T2, or T3.]
Regional lymph nodes (N)
NX: Regional lymph nodes cannot be assessed
N0: No regional lymph node metastasis
N1: Metastasis to ipsilateral peribronchial and/or ipsilateral hilar lymph nodes, and intrapulmonary nodes including involvement by direct extension of the primary tumorN2: Metastasis to ipsilateral mediastinal and/or subcarinal lymph node(s)
N3: Metastasis to contralateral mediastinal, contralateral hilar, ipsilateral or contralateral scalene, or supraclavicular lymph node(s)
Distant metastasis (M)
MX: Distant metastasis cannot be assessed
M0: No distant metastasis
M1: Distant metastasis present. [Note: M1 includes separate tumor nodule(s) in a different lobe (ipsilateral or contralateral).]
Specify sites according to the following notations:BRA = brain EYE = eye HEP = hepatic
LYM = lymph nodes MAR = bone marrow OSS = osseous
OTH = other OVR = ovary PER = peritoneal
PLE = pleura PUL = pulmonary SKI = skin
Occult carcinoma
TX, N0, M0
Stage 0
Tis, N0, M0
Stage IA
T1, N0, M0
Stage IB
T2, N0, M0
Stage IIA
T1, N1, M0
Stage IIB
T2, N1, M0
T3, N0, M0Stage IIIA
T1, N2, M0
T2, N2, M0
T3, N1, M0
T3, N2, M0Stage IIIB
Any T, N3, M0
T4, any N, M0Stage IV
Any T, any N, M1
References
Ginsberg RJ: Invasive and noninvasive techniques of staging in potentially operable lung cancer. Semin Surg Oncol 6 (5): 244-7, 1990. [PUBMED Abstract]
Webb WR, Gatsonis C, Zerhouni EA, et al.: CT and MR imaging in staging non-small cell bronchogenic carcinoma: report of the Radiologic Diagnostic Oncology Group. Radiology 178 (3): 705-13, 1991. [PUBMED Abstract]
Vansteenkiste JF, Stroobants SG, De Leyn PR, et al.: Lymph node staging in non-small-cell lung cancer with FDG-PET scan: a prospective study on 690 lymph node stations from 68 patients. J Clin Oncol 16 (6): 2142-9, 1998. [PUBMED Abstract]
Bülzebruck H, Bopp R, Drings P, et al.: New aspects in the staging of lung cancer. Prospective validation of the International Union Against Cancer TNM classification. Cancer 70 (5): 1102-10, 1992. [PUBMED Abstract]
Mountain CF: Revisions in the International System for Staging Lung Cancer. Chest 111 (6): 1710-7, 1997. [PUBMED Abstract]
Lung. In: American Joint Committee on Cancer.: AJCC Cancer Staging Manual. 6th ed. New York, NY: Springer, 2002, pp 167-181.
In non-small cell lung cancer (NSCLC), results of standard treatment are poor in all but the most localized cancers. All newly diagnosed patients with NSCLC are potential candidates for studies evaluating new forms of treatment. Surgery is the major potentially curative therapeutic option for this disease; radiation therapy can produce cure in a small minority and palliation in the majority of patients. In advanced-stage disease, chemotherapy offers modest improvements in median survival although overall survival is poor.[1,2] Where studied, chemotherapy has been reported to produce short-term improvement in disease-related symptoms. In a single study, symptomatic relief with combination chemotherapy was significant but independent of objective response.[3,4] The impact of chemotherapy on quality of life requires more study.
Current areas under evaluation include combining local (surgery), regional (radiation therapy), and systemic (chemotherapy and immunotherapy) treatments and developing more effective systemic therapy. Several new agents, including paclitaxel (Taxol), docetaxel (Taxotere), topotecan, irinotecan, vinorelbine, and gemcitabine have been shown to be active in the treatment of advanced NSCLC. Chemoprevention of second primary cancers of the upper aerodigestive tract is also under clinical evaluation in patients with early-stage lung cancer.[5]
The designations in PDQ that treatments are "standard" or "under clinical evaluation" are not to be used as a basis for reimbursement determinations.
References
Souquet PJ, Chauvin F, Boissel JP, et al.: Polychemotherapy in advanced non small cell lung cancer: a meta-analysis. Lancet 342 (8862): 19-21, 1993. [PUBMED Abstract]
Chemotherapy in non-small cell lung cancer: a meta-analysis using updated data on individual patients from 52 randomised clinical trials. Non-small Cell Lung Cancer Collaborative Group. BMJ 311 (7010): 899-909, 1995. [PUBMED Abstract]
Hardy JR, Noble T, Smith IE: Symptom relief with moderate dose chemotherapy (mitomycin-C, vinblastine and cisplatin) in advanced non-small cell lung cancer. Br J Cancer 60 (5): 764-6, 1989. [PUBMED Abstract]
Ellis PA, Smith IE, Hardy JR, et al.: Symptom relief with MVP (mitomycin C, vinblastine and cisplatin) chemotherapy in advanced non-small-cell lung cancer. Br J Cancer 71 (2): 366-70, 1995. [PUBMED Abstract]
Pastorino U, Infante M, Maioli M, et al.: Adjuvant treatment of stage I lung cancer with high-dose vitamin A. J Clin Oncol 11 (7): 1216-22, 1993. [PUBMED Abstract]
Occult Non-Small Cell Lung Cancer
Occult non-small cell lung cancer is defined by the following TNM classification:
TX, N0, M0
In occult lung cancer, a diagnostic evaluation often includes chest x-ray and selective bronchoscopy with close follow-up (e.g., computed tomographic scan), when needed, to define the site and nature of the primary tumor; tumors discovered in this fashion are generally early stage and curable by surgery. After discovery of the primary tumor, treatment is determined by establishing the stage of the patient's tumor. Therapy is identical to that recommended for other non-small cell lung cancer patients with similar stage disease.
Stage 0 Non-Small Cell Lung Cancer
Stage 0 non-small cell lung cancer is defined by the following TNM classification:
Tis, N0, M0
Stage 0 non-small cell lung cancer (NSCLC) is the same as carcinoma in situ of the lung. Because these tumors are by definition noninvasive and incapable of metastasizing, they should be curable with surgical resection; however, there is a high incidence of second primary cancers, many of which are unresectable. Endoscopic phototherapy with a hematoporphyrin derivative has been described as an alternative to surgical resection in carefully selected patients.[1-3] This treatment, which is under clinical evaluation, seems to be most effective for very early central tumors that extend less than 1 centimeter within the bronchus.[2] Efficacy of this treatment modality in the management of early NSCLC remains to be proven.
Standard treatment options:
Surgical resection using the least extensive technique possible (segmentectomy or wedge resection) to preserve maximum normal pulmonary tissue since these patients are at high risk for second lung cancers.
Endoscopic photodynamic therapy.[2,3]
References
Woolner LB, Fontana RS, Cortese DA, et al.: Roentgenographically occult lung cancer: pathologic findings and frequency of multicentricity during a 10-year period. Mayo Clin Proc 59 (7): 453-66, 1984. [PUBMED Abstract]
Furuse K, Fukuoka M, Kato H, et al.: A prospective phase II study on photodynamic therapy with photofrin II for centrally located early-stage lung cancer. The Japan Lung Cancer Photodynamic Therapy Study Group. J Clin Oncol 11 (10): 1852-7, 1993. [PUBMED Abstract]
Edell ES, Cortese DA: Photodynamic therapy in the management of early superficial squamous cell carcinoma as an alternative to surgical resection. Chest 102 (5): 1319-22, 1992. [PUBMED Abstract]
Stage I Non-Small Cell Lung Cancer
Note: Some citations in the text of this section are followed by a level of evidence. The PDQ editorial boards use a formal ranking system to help the reader judge the strength of evidence linked to the reported results of a therapeutic strategy. (Refer to the PDQ summary on Levels of Evidence for more information.)
Stage I non-small cell lung cancer is defined by the following TNM classifications:
T1, N0, M0
T2, N0, M0
Surgery is the treatment of choice for patients with stage I non-small cell lung cancer (NSCLC). Careful preoperative assessment of the patient's overall medical condition, especially the patient's pulmonary reserve, is critical in considering the benefits of surgery. The immediate postoperative mortality rate is age-related, but 3% to 5% with lobectomy can be expected.[1] Patients with impaired pulmonary function may be considered for segmental or wedge resection of the primary tumor; the Lung Cancer Study Group has conducted a randomized study (LCSG-821) to compare lobectomy with limited resection for patients with stage I cancer of the lung. The results of this study show a reduction in local recurrence for patients treated with lobectomy compared with those treated with limited excision but no significant difference in overall survival.[2] Similar results have been reported from a nonrandomized comparison of anatomic segmentectomy and lobectomy.[3] A survival advantage was noted with lobectomy for patients with tumors greater than 3 centimeters, but not for those with tumors smaller than 3 centimeters. However, the rate of local/regional recurrence was significantly less after lobectomy, regardless of primary tumor size.
Another study of stage I patients showed that those treated with wedge or segment resections had a local recurrence rate of 50% (31 of 62) despite having undergone complete resections.[4] Exercise testing may aid in the selection of patients with impaired pulmonary function who can tolerate lung resection.[5] The availability of video-assisted thoracoscopic wedge resection permits limited resections in patients with poor pulmonary function who are not usually considered candidates for lobectomy.[6]
Patients with inoperable stage I disease and with sufficient pulmonary reserve may be considered for radiation therapy with curative intent. In a single report of patients older than 70 years of age who had resectable lesions smaller than 4 centimeters but who had medically inoperable disease or who refused surgery, survival at 5 years following radiation therapy with curative intent was comparable to a historical control group of patients of similar age resected with curative intent.[7] In the 2 largest retrospective radiation therapy series, patients with inoperable disease treated with definitive radiation therapy achieved 5-year survival rates of 10% and 27%.[8,9] Both series found that patients with T1, N0 tumors had better outcomes, with 5-year survival rates of 60% and 32% in this subgroup.
Primary radiation therapy should consist of approximately 6,000 cGy delivered with megavoltage equipment to the midplane of the known tumor volume using conventional fractionation. A boost to the cone-down field of the primary tumor is frequently used to further enhance local control. Careful treatment planning with precise definition of target volume and avoidance of critical normal structures to the extent possible is needed for optimal results and requires the use of a simulator.
Many patients treated surgically subsequently develop regional or distant metastases.[4] Therefore, patients should be considered for entry into clinical trials evaluating adjuvant treatment with chemotherapy or radiation therapy following surgery. A meta-analysis of 9 randomized trials evaluating postoperative radiation versus surgery alone showed a 7% reduction in overall survival with adjuvant radiation in patients with stage I or II disease.[10][Level of evidence: 1iiA] It will be important to determine whether these outcomes can potentially be modified with technical improvements, better definitions of target volumes, and limitation of cardiac volume in the radiation portals. Trials of adjuvant chemotherapy regimens have failed to demonstrate a consistent benefit.
In the Lung Cancer Study Group trial of 907 stage T1, N0 resected patients, the rate of nonpulmonary second cancers was 1.8% per year and 1.6% per year for new lung cancers.[11] Others have reported even higher risks of second tumors in long-term survivors, including rates of 10% for second lung cancers and 20% for all second cancers.[4] A randomized trial of vitamin A versus observation in patients with resected stage I disease showed a trend toward decreased second primary cancers in the vitamin A arm with no difference in overall survival rates.[12] Smokers who undergo complete resection of stage I NSCLC are also at risk for second malignant tumors.
An intergroup trial evaluated the role of isotretinoin in the chemoprevention of second cancers in patients with resected stage I NSCLC: 1,116 patients were randomly assigned to receive isotretinoin (30 mg/day) for 3 years or placebo.[13][Level of evidence: 1iiA] (Refer to the PDQ summary on Prevention of Lung Cancer for more information.) After a median follow-up of 3.5 years, there were no differences between the arms with respect to time-to-development of second primary tumors, disease recurrence, or survival.
Standard treatment options:
Lobectomy or segmental,
wedge, or sleeve resection as appropriate.
Radiation therapy with curative intent (for potentially resectable patients
who have medical contraindications to surgery).
Clinical trials of adjuvant chemotherapy following resection.[14,15]
Adjuvant chemoprevention trials.[12,13,16]
Endoscopic photodynamic therapy (under clinical evaluation in highly selected
T1, N0, M0 patients).[17]
Information about ongoing clinical trials is available from the NCI Cancer.gov
Web site.
References
Ginsberg RJ, Hill LD, Eagan RT, et al.: Modern thirty-day operative mortality for surgical resections in lung cancer. J Thorac Cardiovasc Surg 86 (5): 654-8, 1983. [PUBMED Abstract]
Ginsberg RJ, Rubinstein LV: Randomized trial of lobectomy versus limited resection for T1 N0 non-small cell lung cancer. Lung Cancer Study Group. Ann Thorac Surg 60 (3): 615-22; discussion 622-3, 1995. [PUBMED Abstract]
Warren WH, Faber LP: Segmentectomy versus lobectomy in patients with stage I pulmonary carcinoma. Five-year survival and patterns of intrathoracic recurrence. J Thorac Cardiovasc Surg 107 (4): 1087-93; discussion 1093-4, 1994. [PUBMED Abstract]
Martini N, Bains MS, Burt ME, et al.: Incidence of local recurrence and second primary tumors in resected stage I lung cancer. J Thorac Cardiovasc Surg 109 (1): 120-9, 1995. [PUBMED Abstract]
Morice RC, Peters EJ, Ryan MB, et al.: Exercise testing in the evaluation of patients at high risk for complications from lung resection. Chest 101 (2): 356-61, 1992. [PUBMED Abstract]
Shennib HA, Landreneau R, Mulder DS, et al.: Video-assisted thoracoscopic wedge resection of T1 lung cancer in high-risk patients. Ann Surg 218 (4): 555-8; discussion 558-60, 1993. [PUBMED Abstract]
Noordijk EM, vd Poest Clement E, Hermans J, et al.: Radiotherapy as an alternative to surgery in elderly patients with resectable lung cancer. Radiother Oncol 13 (2): 83-9, 1988. [PUBMED Abstract]
Dosoretz DE, Katin MJ, Blitzer PH, et al.: Radiation therapy in the management of medically inoperable carcinoma of the lung: results and implications for future treatment strategies. Int J Radiat Oncol Biol Phys 24 (1): 3-9, 1992. [PUBMED Abstract]
Gauden S, Ramsay J, Tripcony L: The curative treatment by radiotherapy alone of stage I non-small cell carcinoma of the lung. Chest 108 (5): 1278-82, 1995. [PUBMED Abstract]
Postoperative radiotherapy in non-small-cell lung cancer: systematic review and meta-analysis of individual patient data from nine randomised controlled trials. PORT Meta-analysis Trialists Group. Lancet 352 (9124): 257-63, 1998. [PUBMED Abstract]
Thomas P, Rubinstein L: Cancer recurrence after resection: T1 N0 non-small cell lung cancer. Lung Cancer Study Group. Ann Thorac Surg 49 (2): 242-6; discussion 246-7, 1990. [PUBMED Abstract]
Pastorino U, Infante M, Maioli M, et al.: Adjuvant treatment of stage I lung cancer with high-dose vitamin A. J Clin Oncol 11 (7): 1216-22, 1993. [PUBMED Abstract]
Lippman SM, Lee JJ, Karp DD, et al.: Randomized phase III intergroup trial of isotretinoin to prevent second primary tumors in stage I non-small-cell lung cancer. J Natl Cancer Inst 93 (8): 605-18, 2001. [PUBMED Abstract]
Feld R, Rubinstein L, Thomas PA: Adjuvant chemotherapy with cyclophosphamide, doxorubicin, and cisplatin in patients with completely resected stage I non-small-cell lung cancer. The Lung Cancer Study Group. J Natl Cancer Inst 85 (4): 299-306, 1993. [PUBMED Abstract]
Niiranen A, Niitamo-Korhonen S, Kouri M, et al.: Adjuvant chemotherapy after radical surgery for non-small-cell lung cancer: a randomized study. J Clin Oncol 10 (12): 1927-32, 1992. [PUBMED Abstract]
Atkins MB, Eastern Cooperative Oncology Group: Phase III Randomized Chemoprevention Study of Selenium in Participants With Previously Resected Stage I Non-Small Cell Lung Cancer, E-5597, Clinical trial, Active. [PDQ Clinical Trial]
Furuse K, Fukuoka M, Kato H, et al.: A prospective phase II study on photodynamic therapy with photofrin II for centrally located early-stage lung cancer. The Japan Lung Cancer Photodynamic Therapy Study Group. J Clin Oncol 11 (10): 1852-7, 1993. [PUBMED Abstract]
Stage II Non-Small Cell Lung Cancer
Note: Some citations in the text of this section are followed by a level of evidence. The PDQ editorial boards use a formal ranking system to help the reader judge the strength of evidence linked to the reported results of a therapeutic strategy. (Refer to the PDQ summary on Levels of Evidence for more information.)
Stage II non-small cell lung cancer is defined by the following TNM classifications:
T1, N1, M0
T2, N1, M0
T3, N0, M0
Surgery is the treatment of choice for patients with stage II non-small cell lung cancer (NSCLC). Careful preoperative assessment of the patient's overall medical condition, especially the patient's pulmonary reserve, is critical in considering the benefits of surgery. The immediate postoperative mortality rate is age-related, but up to 5% to 8% with pneumonectomy or 3% to 5% with lobectomy can be expected.
Patients with inoperable stage II disease and with sufficient pulmonary reserve may be considered for radiation therapy with curative intent.[1] Among patients with excellent performance status, up to a 20% 3-year survival rate may be expected if a course of radiation therapy with curative intent can be completed. In the largest retrospective series reported to date, 152 patients with medically inoperable NSCLC treated with definitive radiation therapy achieved a 5-year overall survival rate of 10%; however, the 44 patients with T1 tumors achieved an actuarial disease-free survival rate of 60%. This retrospective study also suggested that improved disease-free survival was obtained with radiation therapy doses greater than 6,000 cGy.[2] Primary radiation therapy should consist of approximately 6,000 cGy delivered with megavoltage equipment to the midplane of the volume of known tumor using conventional fractionation. A boost to the cone-down field of the primary tumor is frequently used to further enhance local control. Careful treatment planning with precise definition of target volume and avoidance of critical normal structures to the extent possible is needed for optimal results and requires the use of a simulator.
Many patients treated surgically subsequently develop regional or distant metastases.[3] Therefore, patients should be considered for entry into clinical trials evaluating the use of adjuvant treatment with chemotherapy or radiation therapy following surgery. One controlled trial has failed to demonstrate an overall survival benefit for patients with carefully staged squamous cell carcinoma receiving postoperative irradiation, although local recurrences were significantly reduced.[4] A meta-analysis of 9 randomized trials evaluating postoperative radiation versus surgery alone showed a 7% reduction in overall survival with adjuvant radiation in patients with stage I or II disease.[5][Level of evidence: 1iiA] It will be important to determine whether these outcomes can potentially be modified with technical improvements, better definitions of target volumes, and limitation of cardiac volume in the radiation portals. An intergroup trial comparing postoperative radiation therapy alone to postoperative radiation therapy with concurrent cisplatin and etoposide did not demonstrate either a disease-free or overall survival advantage with the combined therapy.[6][Level of evidence: 1iiA] Based on these data, adjuvant therapy should be considered under clinical evaluation and participation in clinical trials evaluating adjuvant therapy after surgical resection should be encouraged.[7-9]
Standard treatment options:
Lobectomy; pneumonectomy;
or segmental, wedge, or sleeve resection as appropriate.
Radiation therapy with curative intent (for potentially operable patients who
have medical contraindications to surgery).
Clinical trials of adjuvant chemotherapy with or without other modalities following
curative surgery.[10]
Clinical trials of radiation therapy following curative surgery.[10]
Information about ongoing clinical trials is available from the NCI Cancer.gov
Web site.
References
Komaki R, Cox JD, Hartz AJ, et al.: Characteristics of long-term survivors after treatment for inoperable carcinoma of the lung. Am J Clin Oncol 8 (5): 362-70, 1985. [PUBMED Abstract]
Dosoretz DE, Katin MJ, Blitzer PH, et al.: Radiation therapy in the management of medically inoperable carcinoma of the lung: results and implications for future treatment strategies. Int J Radiat Oncol Biol Phys 24 (1): 3-9, 1992. [PUBMED Abstract]
Martini N, Bains MS, Burt ME, et al.: Incidence of local recurrence and second primary tumors in resected stage I lung cancer. J Thorac Cardiovasc Surg 109 (1): 120-9, 1995. [PUBMED Abstract]
Effects of postoperative mediastinal radiation on completely resected stage II and stage III epidermoid cancer of the lung. The Lung Cancer Study Group. N Engl J Med 315 (22): 1377-81, 1986. [PUBMED Abstract]
Postoperative radiotherapy in non-small-cell lung cancer: systematic review and meta-analysis of individual patient data from nine randomised controlled trials. PORT Meta-analysis Trialists Group. Lancet 352 (9124): 257-63, 1998. [PUBMED Abstract]
Keller SM, Adak S, Wagner H, et al.: A randomized trial of postoperative adjuvant therapy in patients with completely resected stage II or IIIA non-small-cell lung cancer. Eastern Cooperative Oncology Group. N Engl J Med 343 (17): 1217-22, 2000. [PUBMED Abstract]
Winton T, NCIC-Clinical Trials Group: Phase III Randomized Study of Adjuvant Vinorelbine and Cisplatin Versus No Adjuvant Chemotherapy in Patients With Completely Resected Non-Small Cell Lung Cancer (Summary Last Modified 07/2001), CAN-NCIC-BR10, Clinical trial, Closed. [PDQ Clinical Trial]
Strauss GM, Cancer and Leukemia Group B: Phase III Randomized Study of Paclitaxel and Carboplatin Versus No Adjuvant Chemotherapy After Resection in Patients With Stage IB Non-Small Cell Lung Cancer, CLB-9633, Clinical trial, Active. [PDQ Clinical Trial]
Bunn PA, Southwest Oncology Group: Phase III Randomized Study of Surgery With or Without Preoperative Paclitaxel and Carboplatin in Patients With Stage IB, II, or Selected IIIA Non-Small Cell Lung Cancer, SWOG-S9900, Clinical trial, Active. [PDQ Clinical Trial]
Holmes EC: Adjuvant treatment in resected lung cancer. Semin Surg Oncol 6 (5): 263-7, 1990. [PUBMED Abstract]
Stage IIIA Non-Small Cell Lung Cancer
Note: Some citations in the text of this section are followed by a level of evidence. The PDQ editorial boards use a formal ranking system to help the reader judge the strength of evidence linked to the reported results of a therapeutic strategy. (Refer to the PDQ summary on Levels of Evidence for more information.)
Stage IIIA non-small cell lung cancer is defined by the following TNM classifications:
T1, N2, M0
T2, N2, M0
T3, N1, M0
T3, N2, M0
Patients with clinical stage IIIA N2 disease have a 5-year survival rate of 10% to 15% overall. However, patients with bulky mediastinal involvement (visible on chest radiograph) have a 5-year survival rate of 2% to 5%. Depending on clinical circumstances, the principal forms of treatment that are considered for patients with stage IIIA non-small cell lung cancer (NSCLC) are radiation therapy, chemotherapy, surgery, and combinations of these modalities. Although the majority of these patients do not achieve a complete response to radiation therapy, there is a reproducible long-term survival benefit in 5% to 10% of patients treated with standard fractionation to 6,000 cGy, and significant palliation often results. Patients with excellent performance status and those who require a thoracotomy to prove that surgically unresectable tumor is present are most likely to benefit from radiation therapy.[1]
Because of the poor long-term results, all patients with stage IIIA NSCLC should be considered for treatment on clinical trials. Trials examining fractionation schedules, brachytherapy, and combined modality approaches may lead to improvement in the control of this disease.[2] One prospective randomized clinical study showed that radiation therapy given as 3 daily fractions improved overall survival compared to radiation therapy given as 1 daily fraction.[3][Level of evidence: 1iiA]
The addition of chemotherapy to radiation therapy has been reported to improve survival in prospective clinical studies that have used modern cisplatin-based chemotherapy regimens.[4-7] A meta-analysis of patient data from 11 randomized clinical trials showed that cisplatin-based combinations plus radiation therapy resulted in a 10% reduction in the risk of death compared with radiation therapy alone.[8] The optimal sequencing of modalities and schedule of drug administration remains to be determined and is under study in ongoing clinical trials.[9]
The use of preoperative (neoadjuvant) chemotherapy has been shown to be effective in 2 small randomized studies of a total of 120 patients with stage IIIA NSCLC.[10,11] The 58 patients randomized to 3 cycles of cisplatin-based chemotherapy followed by surgery had a median survival more than 3 times as long as patients treated with surgery but no chemotherapy in both studies. Two additional single-arm studies have evaluated either 2 to 4 cycles of combination chemotherapy or combination chemotherapy plus chest irradiation for 211 patients with histologically confirmed N2 stage IIIA NSCLC.[12] Sixty-five percent to 75% of patients were able to have a resection of their cancer, and 27% to 28% were alive at 3 years. These results are encouraging, and combined-modality therapy with neoadjuvant chemotherapy with surgery and/or chest radiation therapy should be considered for patients with good performance status who have stage IIIA NSCLC.
Although most retrospective studies suggest that postoperative radiation therapy can improve local control for node-positive patients whose tumors were resected, it remains controversial whether it can improve survival.[13,14] One controlled trial in patients with completely resected stage II or III squamous cell lung cancer failed to demonstrate a survival benefit for patients who received postoperative irradiation, although local recurrences were significantly reduced.[15] A meta-analysis of 9 randomized trials evaluating postoperative radiation therapy versus surgery alone showed no difference in overall survival for the entire postoperative radiation therapy group or for the subset of N2 patients.[16][Level of evidence: 1iiA] It will be important to determine whether these outcomes can potentially be modified with technical improvements, better definitions of target volumes, and limitation of cardiac volume in the radiation portals.
In a trial conducted from 1986 to 1994, patients with completely resected lung cancers that were stage I, II, or IIIA were randomly assigned to resection alone or to resection plus postoperative radiation therapy. The addition of postoperative radiation therapy did not improve overall survival or local recurrence for the whole group or for the subset of patients with stage IIIA disease.[17][Level of evidence: 1iiA] An intergroup trial comparing postoperative radiation therapy alone to postoperative radiation therapy with concurrent cisplatin and etoposide did not demonstrate either a disease-free or overall survival advantage with the combined therapy.[18][Level of evidence: 1iiA] Based on these data, adjuvant therapy should be considered under clinical evaluation and participation in clinical trials evaluating adjuvant therapy after surgical resection should be encouraged.[19-21]
No consistent benefit from any form of immunotherapy has been demonstrated thus far in the treatment of NSCLC.
Standard treatment options:
Surgery alone in operable
patients without bulky lymphadenopathy.[22-24]
Radiation therapy alone, for patients who are not suitable for neoadjuvant chemotherapy
plus surgery.[1,2]
Chemotherapy combined with
other modalities.[4-6,12]
Superior sulcus tumor (T3, N0 or N1, M0)
Another category that merits a special approach is that of superior sulcus tumors, a locally invasive problem usually with a reduced tendency for distant metastases. Consequently, local therapy has curative potential, especially for T3, N0 disease. Radiation therapy alone, radiation therapy preceded or followed by surgery, or surgery alone (in highly selected cases) may be curative in some patients, with a 5-year survival rate of 20% or more in some studies.[25] Patients with more invasive tumors of this area, or true Pancoast tumors, have a worse prognosis and generally do not benefit from primary surgical management. Follow-up surgery may be used to verify complete response in the radiation therapy field and to resect necrotic tissue. Concurrent chemotherapy and radiation therapy followed by surgery may provide the best outcome, particularly for patients with T4, N0 or N1 disease.[26][Level of evidence: 3iiiDi]
Standard treatment options:
Radiation therapy and surgery.
Radiation therapy alone.
Surgery alone (selected cases).
Chemotherapy combined with other modalities.
Clinical trials of combined modality therapy.
Information about ongoing clinical trials is available from the NCI Cancer.gov
Web site.
Chest wall tumor (T3, N0 or N1, M0)
Selected patients with bulky primary tumors that directly invade the chest wall can obtain long-term survival with surgical management provided that their tumor is completely resected.
Standard treatment options:
Surgery.[24,27]
Surgery and radiation therapy.
Radiation therapy alone.
Chemotherapy combined with other modalities.
References
Komaki R, Cox JD, Hartz AJ, et al.: Characteristics of long-term survivors after treatment for inoperable carcinoma of the lung. Am J Clin Oncol 8 (5): 362-70, 1985. [PUBMED Abstract]
Johnson DH, Einhorn LH, Bartolucci A, et al.: Thoracic radiotherapy does not prolong survival in patients with locally advanced, unresectable non-small cell lung cancer. Ann Intern Med 113 (1): 33-8, 1990. [PUBMED Abstract]
Saunders M, Dische S, Barrett A, et al.: Continuous hyperfractionated accelerated radiotherapy (CHART) versus conventional radiotherapy in non-small-cell lung cancer: a randomised multicentre trial. CHART Steering Committee. Lancet 350 (9072): 161-5, 1997. [PUBMED Abstract]
Dillman RO, Seagren SL, Propert KJ, et al.: A randomized trial of induction
chemotherapy plus high-dose radiation versus radiation alone in stage III non-small-cell
lung cancer. N Engl J Med 323 (14): 940-5, 1990. [PUBMED Abstract]
Le Chevalier T, Arriagada R, Quoix E, et al.: Radiotherapy alone versus combined chemotherapy and radiotherapy in nonresectable non-small-cell lung cancer: first analysis of a randomized trial in 353 patients. J Natl Cancer Inst 83 (6): 417-23, 1991. [PUBMED Abstract]
Schaake-Koning C, van den Bogaert W, Dalesio O, et al.: Effects of concomitant cisplatin and radiotherapy on inoperable non-small-cell lung cancer. N Engl J Med 326 (8): 524-30, 1992. [PUBMED Abstract]
Sause WT, Scott C, Taylor S, et al.: Radiation Therapy Oncology Group (RTOG) 88-08 and Eastern Cooperative Oncology Group (ECOG) 4588: preliminary results of a phase III trial in regionally advanced, unresectable non-small-cell lung cancer. J Natl Cancer Inst 87 (3): 198-205, 1995. [PUBMED Abstract]
Chemotherapy in non-small cell lung cancer: a meta-analysis using updated data on individual patients from 52 randomised clinical trials. Non-small Cell Lung Cancer Collaborative Group. BMJ 311 (7010): 899-909, 1995. [PUBMED Abstract]
Curran WJ, Radiation Therapy Oncology Group: Phase III Randomized Study of Standard Thoracic Irradiation Following VBL/CDDP vs Standard Thoracic Irradiation and Concurrent VBL/CDDP vs Hyperfractionated Thoracic Irradiation and Concurrent VP-16/CDDP for Locally Advanced, Unresectable, non-Small Cell Lung Cancer (Summary Last Modified 09/98), RTOG-9410, Clinical trial, Closed. [PDQ Clinical Trial]
Rosell R, Gómez-Codina J, Camps C, et al.: A randomized trial comparing preoperative chemotherapy plus surgery with surgery alone in patients with non-small-cell lung cancer. N Engl J Med 330 (3): 153-8, 1994. [PUBMED Abstract]
Roth JA, Fossella F, Komaki R, et al.: A randomized trial comparing perioperative chemotherapy and surgery with surgery alone in resectable stage IIIA non-small-cell lung cancer. J Natl Cancer Inst 86 (9): 673-80, 1994. [PUBMED Abstract]
Albain KS, Rusch VW, Crowley JJ, et al.: Concurrent cisplatin/etoposide plus chest radiotherapy followed by surgery for stages IIIA (N2) and IIIB non-small-cell lung cancer: mature results of Southwest Oncology Group phase II study 8805. J Clin Oncol 13 (8): 1880-92, 1995. [PUBMED Abstract]
Emami B, Kaiser L, Simpson J, et al.: Postoperative radiation therapy in non-small cell lung cancer. Am J Clin Oncol 20 (5): 441-8, 1997. [PUBMED Abstract]
Sawyer TE, Bonner JA, Gould PM, et al.: Effectiveness of postoperative irradiation in stage IIIA non-small cell lung cancer according to regression tree analyses of recurrence risks. Ann Thorac Surg 64 (5): 1402-7; discussion 1407-8, 1997. [PUBMED Abstract]
Effects of postoperative mediastinal radiation on completely resected stage II and stage III epidermoid cancer of the lung. The Lung Cancer Study Group. N Engl J Med 315 (22): 1377-81, 1986. [PUBMED Abstract]
Postoperative radiotherapy in non-small-cell lung cancer: systematic review and meta-analysis of individual patient data from nine randomised controlled trials. PORT Meta-analysis Trialists Group. Lancet 352 (9124): 257-63, 1998. [PUBMED Abstract]
Dautzenberg B, Arriagada R, Chammard AB, et al.: A controlled study of postoperative radiotherapy for patients with completely resected nonsmall cell lung carcinoma. Groupe d'Etude et de Traitement des Cancers Bronchiques. Cancer 86 (2): 265-73, 1999. [PUBMED Abstract]
Keller SM, Adak S, Wagner H, et al.: A randomized trial of postoperative adjuvant therapy in patients with completely resected stage II or IIIA non-small-cell lung cancer. Eastern Cooperative Oncology Group. N Engl J Med 343 (17): 1217-22, 2000. [PUBMED Abstract]
Winton T, NCIC-Clinical Trials Group: Phase III Randomized Study of Adjuvant Vinorelbine and Cisplatin Versus No Adjuvant Chemotherapy in Patients With Completely Resected Non-Small Cell Lung Cancer (Summary Last Modified 07/2001), CAN-NCIC-BR10, Clinical trial, Closed. [PDQ Clinical Trial]
Strauss GM, Cancer and Leukemia Group B: Phase III Randomized Study of Paclitaxel and Carboplatin Versus No Adjuvant Chemotherapy After Resection in Patients With Stage IB Non-Small Cell Lung Cancer, CLB-9633, Clinical trial, Active. [PDQ Clinical Trial]
Bunn PA, Southwest Oncology Group: Phase III Randomized Study of Surgery With or Without Preoperative Paclitaxel and Carboplatin in Patients With Stage IB, II, or Selected IIIA Non-Small Cell Lung Cancer, SWOG-S9900, Clinical trial, Active. [PDQ Clinical Trial]
Shields TW: The significance of ipsilateral mediastinal lymph node metastasis (N2 disease) in non-small cell carcinoma of the lung. A commentary. J Thorac Cardiovasc Surg 99 (1): 48-53, 1990. [PUBMED Abstract]
Mountain CF: The biological operability of stage III non-small cell lung cancer. Ann Thorac Surg 40 (1): 60-4, 1985. [PUBMED Abstract]
Van Raemdonck DE, Schneider A, Ginsberg RJ: Surgical treatment for higher stage non-small cell lung cancer. Ann Thorac Surg 54 (5): 999-1013, 1992. [PUBMED Abstract]
Komaki R, Mountain CF, Holbert JM, et al.: Superior sulcus tumors: treatment selection and results for 85 patients without metastasis (Mo) at presentation. Int J Radiat Oncol Biol Phys 19 (1): 31-6, 1990. [PUBMED Abstract]
Rusch VW, Giroux DJ, Kraut MJ, et al.: Induction chemoradiation and surgical
resection for non-small cell lung carcinomas of the superior sulcus: Initial
results of Southwest Oncology Group Trial 9416 (Intergroup Trial 0160). J Thorac
Cardiovasc Surg 121 (3): 472-83, 2001. [PUBMED Abstract]
McCaughan BC, Martini N, Bains MS, et al.: Chest wall invasion in carcinoma of the lung. Therapeutic and prognostic implications. J Thorac Cardiovasc Surg 89 (6): 836-41, 1985. [PUBMED Abstract]
Stage IIIB Non-Small Cell Lung Cancer
Stage IIIB non-small cell lung cancer is defined by the following TNM classifications:
Any T, N3, M0
T4, any N, M0
Note: Some citations in the text of this section are followed by a level of evidence. The PDQ editorial boards use a formal ranking system to help the reader judge the strength of evidence linked to the reported results of a therapeutic strategy. (Refer to the PDQ summary on Levels of Evidence for more information.)
Patients with stage IIIB non-small cell lung cancer (NSCLC) do not benefit from surgery alone and are best managed by initial chemotherapy, chemotherapy plus radiation therapy, or radiation therapy alone, depending on sites of tumor involvement and performance status. Most patients with excellent performance status should be considered for combined modality therapy. However, patients with malignant pleural effusion are rarely candidates for radiation therapy, and should generally be treated similarly to stage IV patients (see separate section of this summary on treatment of stage IV disease). Many randomized studies of patients with unresectable stage III NSCLC show that treatment with neoadjuvant or concurrent cisplatin-based chemotherapy and chest irradiation is associated with improved survival compared to treatment with radiation therapy alone.[1-5] A meta-analysis of patient data from 11 randomized clinical trials showed that cisplatin-based combinations plus radiation therapy resulted in a 10% reduction in the risk of death compared with radiation therapy alone.[6]
Patients with stage IIIB disease with poor performance status are candidates for chest irradiation to palliate pulmonary symptoms (e.g., cough, shortness of breath, hemoptysis, or pain).[7][Level of evidence: 3iiiC]
T4 or N3, M0
An occasional patient with supraclavicular node involvement who is otherwise a good candidate for irradiation with curative intent will survive 3 years. Although the majority of these patients do not achieve a complete response to radiation therapy, significant palliation often results. Patients with excellent performance status and those who are found to have advanced-stage disease at the time of resection are most likely to benefit from radiation therapy.[8] Adjuvant systemic chemotherapy with radiation therapy has been tested in randomized trials for patients with inoperable or unresectable locoregional NSCLC.[1-3,9] Some patients have shown a modest survival advantage with adjuvant chemotherapy. The addition of chemotherapy to radiation therapy has been reported to improve long-term survival in some,[1,3,4] but not all,[10] prospective clinical studies. A meta-analysis of patient data from 54 randomized clinical trials showed an absolute survival benefit of 4% at 2 years with the addition of cisplatin-based chemotherapy to radiation therapy.[11] The optimal sequencing of modalities remains to be determined and is under study in ongoing clinical trials.[12]
Because of the poor overall results, these patients should be considered for clinical trials; trials examining new fractionation schedules, radiosensitizers, and combined modality approaches may lead to improvement in the control of disease. Information about ongoing clinical trials is available from the NCI Cancer.gov Web site.
Patients with NSCLC can present with superior vena cava syndrome. (Refer to the PDQ summary on Superior Vena Cava Syndrome for more information.) Regardless of stage, this problem should generally be managed with radiation therapy with or without chemotherapy.
Standard treatment options:
Radiation therapy alone.[7]
Chemotherapy combined with radiation therapy.[1-3,9]
Chemotherapy and concurrent radiation therapy followed by resection.[13,14]
Chemotherapy alone.
References
Le Chevalier T, Arriagada R, Quoix E, et al.: Radiotherapy alone versus combined chemotherapy and radiotherapy in nonresectable non-small-cell lung cancer: first analysis of a randomized trial in 353 patients. J Natl Cancer Inst 83 (6): 417-23, 1991. [PUBMED Abstract]
Morton RF, Jett JR, McGinnis WL, et al.: Thoracic radiation therapy alone compared with combined chemoradiotherapy for locally unresectable non-small cell lung cancer. A randomized, phase III trial. Ann Intern Med 115 (9): 681-6, 1991. [PUBMED Abstract]
Dillman RO, Seagren SL, Propert KJ, et al.: A randomized trial of induction chemotherapy plus high-dose radiation versus radiation alone in stage III non-small-cell lung cancer. N Engl J Med 323 (14): 940-5, 1990. [PUBMED Abstract]
Schaake-Koning C, van den Bogaert W, Dalesio O, et al.: Effects of concomitant cisplatin and radiotherapy on inoperable non-small-cell lung cancer. N Engl J Med 326 (8): 524-30, 1992. [PUBMED Abstract]
Sause WT, Scott C, Taylor S, et al.: Radiation Therapy Oncology Group (RTOG)
88-08 and Eastern Cooperative Oncology Group (ECOG) 4588: preliminary results
of a phase III trial in regionally advanced, unresectable non-small-cell lung
cancer. J Natl Cancer Inst 87 (3): 198-205, 1995. [PUBMED Abstract]
Chemotherapy in non-small cell lung cancer: a meta-analysis using updated data on individual patients from 52 randomised clinical trials. Non-small Cell Lung Cancer Collaborative Group. BMJ 311 (7010): 899-909, 1995. [PUBMED Abstract]
Langendijk JA, ten Velde GP, Aaronson NK, et al.: Quality of life after palliative radiotherapy in non-small cell lung cancer: a prospective study. Int J Radiat Oncol Biol Phys 47 (1): 149-55, 2000. [PUBMED Abstract]
Komaki R, Cox JD, Hartz AJ, et al.: Characteristics of long-term survivors after treatment for inoperable carcinoma of the lung. Am J Clin Oncol 8 (5): 362-70, 1985. [PUBMED Abstract]
Ihde DC: Chemotherapy combined with chest irradiation for locally advanced non-small cell lung cancer. Ann Intern Med 115 (9): 737-9, 1991. [PUBMED Abstract]
Blanke C, Ansari R, Mantravadi R, et al.: Phase III trial of thoracic irradiation with or without cisplatin for locally advanced unresectable non-small-cell lung cancer: a Hoosier Oncology Group protocol. J Clin Oncol 13 (6): 1425-9, 1995. [PUBMED Abstract]
Pignon JP, Stewart LA, Souhami RL, et al.: A meta-analysis using individual patient data from randomised clinical trials (RCTS) of chemotherapy (CT) in non-small cell lung cancer (NSCLC): (2) survival in the locally advanced (LA) setting. [Abstract] Proceedings of the American Society of Clinical Oncology 13: A-1109, 334, 1994.
Curran WJ, Radiation Therapy Oncology Group: Phase III Randomized Study of Standard Thoracic Irradiation Following VBL/CDDP vs Standard Thoracic Irradiation and Concurrent VBL/CDDP vs Hyperfractionated Thoracic Irradiation and Concurrent VP-16/CDDP for Locally Advanced, Unresectable, non-Small Cell Lung Cancer (Summary Last Modified 09/98), RTOG-9410, Clinical trial, Closed. [PDQ Clinical Trial]
Rusch VW, Albain KS, Crowley JJ, et al.: Surgical resection of stage IIIA and stage IIIB non-small-cell lung cancer after concurrent induction chemoradiotherapy. A Southwest Oncology Group trial. J Thorac Cardiovasc Surg 105 (1): 97-104; discussion 104-6, 1993. [PUBMED Abstract]
Albain KS, Rusch VW, Crowley JJ, et al.: Concurrent cisplatin/etoposide plus chest radiotherapy followed by surgery for stages IIIA (N2) and IIIB non-small-cell lung cancer: mature results of Southwest Oncology Group phase II study 8805. J Clin Oncol 13 (8): 1880-92, 1995. [PUBMED Abstract]
Stage IV Non-Small Cell Lung Cancer
Note: Some citations in the text of this section are followed by a level of evidence. The PDQ editorial boards use a formal ranking system to help the reader judge the strength of evidence linked to the reported results of a therapeutic strategy. (Refer to the PDQ summary on Levels of Evidence for more information.)
Stage IV non-small cell lung cancer is defined by the following TNM classification:
Any T, any N, M1
Palliative chemotherapy with a cisplatin- or carboplatin-based regimen has been associated with objective and subjective responses for patients with metastatic non-small cell lung cancer. Randomized trials have shown that cisplatin-based chemotherapy produces modest benefits in short-term survival compared to supportive care alone in patients with inoperable stage IIIB or IV disease. Although toxic effects may vary, outcomes are similar with most platinum-containing regimens. A prospective randomized trial comparing 5 older cisplatin-containing regimens showed no significant difference in response, duration of response, or survival among the different cisplatin-based regimens.[1][Level of evidence: 1iiA] Patients with good performance status and a limited number of sites of distant metastases have superior response and survival when given chemotherapy as compared to other patients.[2] A prospective randomized comparison of vinorelbine plus cisplatin versus vindesine plus cisplatin versus single agent vinorelbine has reported improved response rate (30%) and median survival (40 weeks) with the vinorelbine plus cisplatin regimen, compared to the other 2 regimens.[3][Level of evidence: 1iiA
Reports of taxane/platinum combinations have shown relatively high response rates, significant 1-year survival, and palliation of lung cancer symptoms.[4] In single institution phase II studies that evaluated the paclitaxel plus carboplatin regimen, response rates have been in the range of 27% to 53% with 1-year survival rates of 32% to 54%.[4,5] In a multicenter phase III study, the combination of cisplatin and paclitaxel was shown to have a higher response rate than the older combination of cisplatin and etoposide.[6][Level of evidence: 1iiDi] Similar response rates, survival, and quality of life outcomes were found for patients 70 years of age and older compared to patients younger than 70 years of age despite more comorbid conditions and higher frequency of leukopenia, weight loss, and neuropsychiatric toxic effects among the older patients.[7,8]
A prospective randomized study compared 4 commonly used platinum-based chemotherapy regimens for patients with stage IIIB or IV non-small cell lung cancer: cisplatin/paclitaxel, gemcitabine/cisplatin, cisplatin/docetaxel, and carboplatin/paclitaxel.[9] No regimen was found to have a significantly better response rate or survival.[9][Level of evidence: 1iiA] The response rate for all 1158 eligible patients was 19%, while the median survival was 7.9 months (95% confidence interval, 7.3 to 8.5 months). Patients with a performance status of 2 had significantly worse toxic effects and survival compared to patients with a performance status of 0 to 1.[10] Another prospective randomized study compared the combination of carboplatin/paclitaxel with vinorelbine/cisplatin. This study also found no significant difference in efficacy between these 2 standard regimens.[6][Level of evidence: 1iiDi]
Although these results support further evaluation of chemotherapeutic approaches for both metastatic and locally advanced non-small cell lung cancer (NSCLC), efficacy of current platinum-based chemotherapy combinations is such that no specific regimen can be regarded as standard therapy. Appropriate patients should be encouraged to participate in clinical trials evaluating the role of platinum-based and non-platinum-based chemotherapy. Outside of a clinical trial setting, chemotherapy should be given only to patients with good performance status and evaluable tumor lesions who desire such treatment after being fully informed of its anticipated risks and limited benefits.
Radiation therapy may be effective in palliating symptomatic local involvement with NSCLC such as tracheal, esophageal, or bronchial compression, bone or brain metastases, pain, vocal cord paralysis, hemoptysis, or superior vena cava syndrome. In some cases, endobronchial laser therapy and/or brachytherapy has been used to alleviate proximal obstructing lesions.[11] Such therapeutic intervention may be critical in the prolongation of an acceptable lifestyle in an otherwise functional patient. In the rare patient with synchronous presentation of a resectable primary tumor in the lung and a single brain metastasis, surgical resection of the solitary brain lesion is indicated with resection of the primary tumor and appropriate postoperative chemotherapy and/or irradiation of the primary tumor site and with postoperative whole-brain irradiation delivered in daily fractions of 180 cGy to 200 cGy to avoid long-term toxic effects to normal brain tissue.[12,13]
In asymptomatic patients kept under close observation, treatment may often be appropriately deferred until symptoms or signs of progressive tumor develop.
Standard treatment options:
External-beam radiation
therapy, primarily for palliative relief of local symptomatic tumor growth.
Chemotherapy. The following regimens are associated with similar survival outcomes:
Cisplatin plus vinblastine plus mitomycin.[14]
Cisplatin plus vinorelbine.[3,15]
Cisplatin plus paclitaxel.[6,9]
Cisplatin plus docetaxel.[9,16]
Cisplatin plus gemcitabine.[9,17]
Carboplatin plus paclitaxel.[5,9,15]
Clinical trials evaluating
the role of new chemotherapy regimens and other systemic agents. Initial results
suggest newer non-platinum-based chemotherapy regimens may produce response
and survival results similar to those produced by standard platinum-based regimens.[18]
Further trials comparing platinum- and non-platinum-based regimens are ongoing.
Information about ongoing clinical trials is available from the NCI Cancer.gov
Web site.
Endobronchial laser therapy and/or brachytherapy for obstructing lesions.[11]
References
Weick JK, Crowley J, Natale RB, et al.: A randomized trial of five cisplatin-containing treatments in patients with metastatic non-small-cell lung cancer: a Southwest Oncology Group study. J Clin Oncol 9 (7): 1157-62, 1991. [PUBMED Abstract]
O'Connell JP, Kris MG, Gralla RJ, et al.: Frequency and prognostic importance of pretreatment clinical characteristics in patients with advanced non-small-cell lung cancer treated with combination chemotherapy. J Clin Oncol 4 (11): 1604-14, 1986. [PUBMED Abstract]
Le Chevalier T, Brisgand D, Douillard JY, et al.: Randomized study of vinorelbine and cisplatin versus vindesine and cisplatin versus vinorelbine alone in advanced non-small-cell lung cancer: results of a European multicenter trial including 612 patients. J Clin Oncol 12 (2): 360-7, 1994. [PUBMED Abstract]
Johnson DH, Paul DM, Hande KR, et al.: Paclitaxel plus carboplatin in advanced non-small-cell lung cancer: a phase II trial. J Clin Oncol 14 (7): 2054-60, 1996. [PUBMED Abstract]
Langer CJ, Leighton JC, Comis RL, et al.: Paclitaxel and carboplatin in combination in the treatment of advanced non-small-cell lung cancer: a phase II toxicity, response, and survival analysis. J Clin Oncol 13 (8): 1860-70, 1995. [PUBMED Abstract]
Bonomi P, Kim K, Fairclough D, et al.: Comparison of survival and quality of life in advanced non-small-cell lung cancer patients treated with two dose levels of paclitaxel combined with cisplatin versus etoposide with cisplatin: results of an Eastern Cooperative Oncology Group trial. J Clin Oncol 18 (3): 623-31, 2000. [PUBMED Abstract]
Langer CJ, Manola J, Bernardo P, et al.: Cisplatin-based therapy for elderly patients with advanced non-small-cell lung cancer: implications of Eastern Cooperative Oncology Group 5592, a randomized trial. J Natl Cancer Inst 94 (3): 173-81, 2002. [PUBMED Abstract]
Perrone F, Gallo C, Gridelli C: Re: Cisplatin-based therapy for elderly patients with advanced non-small-cell lung cancer: implications of Eastern Cooperative Oncology Group 5592, a randomized trial. J Natl Cancer Inst 94 (13): 1029-30; discussion 1030-1, 2002. [PUBMED Abstract]
Schiller JH, Harrington D, Sandler A, et al.: A randomized phase III trial of four chemotherapy regimens in advanced non-small cell lung cancer (NSCLC). [Abstract] Proceedings of the American Society of Clinical Oncology 19: A-2, 1a, 2000.
Schiller JH, Harrington D, Belani CP, et al.: Comparison of four chemotherapy regimens for advanced non-small-cell lung cancer. N Engl J Med 346 (2): 92-8, 2002. [PUBMED Abstract]
Miller JI Jr, Phillips TW: Neodymium:YAG laser and brachytherapy in the management of inoperable bronchogenic carcinoma. Ann Thorac Surg 50 (2): 190-5; discussion 195-6, 1990. [PUBMED Abstract]
Mandell L, Hilaris B, Sullivan M, et al.: The treatment of single brain metastasis
from non-oat cell lung carcinoma. Surgery and radiation versus radiation therapy
alone. Cancer 58 (3): 641-9, 1986. [PUBMED Abstract]
DeAngelis LM, Mandell LR, Thaler HT, et al.: The role of postoperative radiotherapy after resection of single brain metastases. Neurosurgery 24 (6): 798-805, 1989. [PUBMED Abstract]
Veeder MH, Jett JR, Su JQ, et al.: A phase III trial of mitomycin C alone versus mitomycin C, vinblastine, and cisplatin for metastatic squamous cell lung carcinoma. Cancer 70 (9): 2281-7, 1992. [PUBMED Abstract]
Kelly K, Crowley J, Bunn PA Jr, et al.: Randomized phase III trial of paclitaxel plus carboplatin versus vinorelbine plus cisplatin in the treatment of patients with advanced non--small-cell lung cancer: a Southwest Oncology Group trial. J Clin Oncol 19 (13): 3210-8, 2001. [PUBMED Abstract]
Belani CP: Docetaxel (Taxotere) in combination with platinum-based regimens in non-small cell lung cancer: results and future developments. Semin Oncol 26 (3 Suppl 10): 15-8, 1999. [PUBMED Abstract]
Sandler AB, Nemunaitis J, Denham C, et al.: Phase III trial of gemcitabine plus cisplatin versus cisplatin alone in patients with locally advanced or metastatic non-small-cell lung cancer. J Clin Oncol 18 (1): 122-30, 2000. [PUBMED Abstract]
Kosmidis P, Mylonakis N, Nicolaides C, et al.: Paclitaxel plus carboplatin versus gemcitabine plus paclitaxel in advanced non-small-cell lung cancer: a phase III randomized trial. J Clin Oncol 20 (17): 3578-85, 2002. [PUBMED Abstract]
Recurrent Non-Small Cell Lung Cancer
Note: Some citations in the text of this section are followed by a level of evidence. The PDQ editorial boards use a formal ranking system to help the reader judge the strength of evidence linked to the reported results of a therapeutic strategy. (Refer to the PDQ summary on Levels of Evidence for more information.)
Many patients with recurrent non-small cell lung cancer (NSCLC) are eligible for clinical trials. Radiation therapy may provide excellent palliation of symptoms from a localized tumor mass.
Patients who present with a solitary cerebral metastasis after resection of a primary NSCLC lesion and who have no evidence of extracranial tumor can achieve prolonged disease-free survival with surgical excision of the brain metastasis and postoperative whole-brain irradiation.[1,2] Unresectable brain metastases in this setting may be treated radiosurgically.[3] Because of the small potential for long-term survival, radiation therapy should be delivered by conventional methods in daily doses of 180 to 200 cGy, while higher daily doses over a shorter period of time (hypofractionated schemes) should be avoided because of the high risk of toxic effects observed with such treatments.[4] Most patients not suitable for surgical resection should receive conventional whole-brain radiation therapy. Selected patients with good performance status and small metastases can be considered for stereotactic radiosurgery.[5]
Approximately one half of patients treated with resection and postoperative radiation therapy will develop recurrence in the brain; some of these patients will be suitable for additional treatment.[6] In those selected patients with good performance status and without progressive metastases outside of the brain, treatment options include reoperation or stereotactic radiosurgery.[3,6] For most patients, additional radiation therapy can be considered; however, the palliative benefit of this treatment is limited.[7][Level of evidence: 3iiiDii]
A solitary pulmonary metastasis from an initially resected bronchogenic carcinoma is unusual. The lung is frequently the site of second primary malignancies in patients with primary lung cancers. Determining whether the new lesion is a new primary cancer or a metastasis may be difficult. Studies have indicated that in the majority of patients the new lesion is a second primary tumor, and following resection some patients may achieve long-term survival. Thus, if the first primary tumor has been controlled, the second primary tumor should be resected if possible.[8,9]
The use of chemotherapy has produced objective responses and small improvement in survival for patients with metastatic disease.[10][Level of evidence: 1iiA] In studies that have examined symptomatic response, improvement in subjective symptoms has been reported to occur more frequently than objective response.[11,12] Informed patients with good performance status and symptomatic recurrence can be offered treatment with a platinum-based chemotherapy regimen for palliation of symptoms. For patients who have relapsed following platinum-based chemotherapy, second-line treatment can be considered. Two prospective randomized studies have shown an improvement in survival with the use of docetaxel compared to vinorelbine, ifosfamide, or best supportive care.[13,14] However, criteria for the selection of appropriate patients for second-line treatment are not well-defined.[15]
Standard treatment options:
Palliative radiation therapy.
Chemotherapy alone. For patients who have not received prior chemotherapy, the
following regimens are associated with similar survival outcomes:
Cisplatin plus vinblastine plus mitomycin.[16]
Cisplatin plus vinorelbine.[17]
Cisplatin plus paclitaxel.[18,19]
Cisplatin plus gemcitabine.[19,20]
Carboplatin plus paclitaxel.[19,21,22]
Cisplatin plus docetaxel.[19]
Surgical resection of isolated
cerebral metastasis (highly selected patients).[6]
Laser therapy or interstitial radiation therapy for endobronchial lesions.[23]
Stereotactic radiosurgery (highly selected patients).[3,5]
References
Patchell RA, Tibbs PA, Walsh JW, et al.: A randomized trial of surgery in the treatment of single metastases to the brain. N Engl J Med 322 (8): 494-500, 1990. [PUBMED Abstract]
Mandell L, Hilaris B, Sullivan M, et al.: The treatment of single brain metastasis from non-oat cell lung carcinoma. Surgery and radiation versus radiation therapy alone. Cancer 58 (3): 641-9, 1986. [PUBMED Abstract]
Loeffler JS, Kooy HM, Wen PY, et al.: The treatment of recurrent brain metastases with stereotactic radiosurgery. J Clin Oncol 8 (4): 576-82, 1990. [PUBMED Abstract]
DeAngelis LM, Mandell LR, Thaler HT, et al.: The role of postoperative radiotherapy after resection of single brain metastases. Neurosurgery 24 (6): 798-805, 1989. [PUBMED Abstract]
Alexander E 3rd, Moriarty TM, Davis RB, et al.: Stereotactic radiosurgery for the definitive, noninvasive treatment of brain metastases. J Natl Cancer Inst 87 (1): 34-40, 1995. [PUBMED Abstract]
Arbit E, Wronski M, Burt M, et al.: The treatment of patients with recurrent brain metastases. A retrospective analysis of 109 patients with nonsmall cell lung cancer. Cancer 76 (5): 765-73, 1995. [PUBMED Abstract]
Hazuka MB, Kinzie JJ: Brain metastases: results and effects of re-irradiation. Int J Radiat Oncol Biol Phys 15 (2): 433-7, 1988. [PUBMED Abstract]
Salerno TA, Munro DD, Blundell PE, et al.: Second primary bronchogenic carcinoma: life-table analysis of surgical treatment. Ann Thorac Surg 27 (1): 3-6, 1979. [PUBMED Abstract]
Yellin A, Hill LR, Benfield JR: Bronchogenic carcinoma associated with upper aerodigestive cancers. J Thorac Cardiovasc Surg 91 (5): 674-83, 1986. [PUBMED Abstract]
Souquet PJ, Chauvin F, Boissel JP, et al.: Polychemotherapy in advanced non small cell lung cancer: a meta-analysis. Lancet 342 (8862): 19-21, 1993. [PUBMED Abstract]
Ellis PA, Smith IE, Hardy JR, et al.: Symptom relief with MVP (mitomycin C, vinblastine and cisplatin) chemotherapy in advanced non-small-cell lung cancer. Br J Cancer 71 (2): 366-70, 1995. [PUBMED Abstract]
Girling DJ, et al.: Randomized trial of etoposide cyclophosphamide methotrexate and vincristine versus etoposide and vincristine in the palliative treatment of patients with small-cell lung cancer and poor prognosis. Br J Cancer 67(Suppl 20): A-4;2, 14, 1993.
Fossella FV, DeVore R, Kerr RN, et al.: Randomized phase III trial of docetaxel
versus vinorelbine or ifosfamide in patients with advanced non-small-cell lung
cancer previously treated with platinum-containing chemotherapy regimens. The
TAX 320 Non-Small Cell Lung Cancer Study Group. J Clin Oncol 18 (12): 2354-62,
2000. [PUBMED Abstract]
Shepherd FA, Dancey J, Ramlau R, et al.: Prospective randomized trial of docetaxel versus best supportive care in patients with non-small-cell lung cancer previously treated with platinum-based chemotherapy. J Clin Oncol 18 (10): 2095-103, 2000. [PUBMED Abstract]
Huisman C, Smit EF, Giaccone G, et al.: Second-line chemotherapy in relapsing or refractory non-small-cell lung cancer: a review. J Clin Oncol 18 (21): 3722-30, 2000. [PUBMED Abstract]
Veeder MH, Jett JR, Su JQ, et al.: A phase III trial of mitomycin C alone versus mitomycin C, vinblastine, and cisplatin for metastatic squamous cell lung carcinoma. Cancer 70 (9): 2281-7, 1992. [PUBMED Abstract]
Le Chevalier T, Brisgand D, Douillard JY, et al.: Randomized study of vinorelbine and cisplatin versus vindesine and cisplatin versus vinorelbine alone in advanced non-small-cell lung cancer: results of a European multicenter trial including 612 patients. J Clin Oncol 12 (2): 360-7, 1994. [PUBMED Abstract]
Bonomi P, Kim K, Fairclough D, et al.: Comparison of survival and quality of life in advanced non-small-cell lung cancer patients treated with two dose levels of paclitaxel combined with cisplatin versus etoposide with cisplatin: results of an Eastern Cooperative Oncology Group trial. J Clin Oncol 18 (3): 623-31, 2000. [PUBMED Abstract]
Schiller JH, Harrington D, Sandler A, et al.: A randomized phase III trial of four chemotherapy regimens in advanced non-small cell lung cancer (NSCLC). [Abstract] Proceedings of the American Society of Clinical Oncology 19: A-2, 1a, 2000.
Sandler AB, Nemunaitis J, Denham C, et al.: Phase III trial of gemcitabine plus cisplatin versus cisplatin alone in patients with locally advanced or metastatic non-small-cell lung cancer. J Clin Oncol 18 (1): 122-30, 2000. [PUBMED Abstract]
Johnson DH, Paul DM, Hande KR, et al.: Paclitaxel plus carboplatin in advanced non-small-cell lung cancer: a phase II trial. J Clin Oncol 14 (7): 2054-60, 1996. [PUBMED Abstract]
Langer CJ, Leighton JC, Comis RL, et al.: Paclitaxel and carboplatin in combination in the treatment of advanced non-small-cell lung cancer: a phase II toxicity, response, and survival analysis. J Clin Oncol 13 (8): 1860-70, 1995. [PUBMED Abstract]
Miller JI Jr, Phillips TW: Neodymium:YAG laser and brachytherapy in the management of inoperable bronchogenic carcinoma. Ann Thorac Surg 50 (2): 190-5; discussion 195-6, 1990. [PUBMED Abstract]
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